DESDE CARACOLLO_ORURO_ BOLIVIA R-DJ_DJ_RUBEN QUISPE F.

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LENTO VIOLENTO DJ _RUBEN CREACIONES OFICIALES Y CREATIVIDAD PROPIA
DESCARGAS ABIERTAS DE DOWLOAND CLICK FLECHA NEGRA PARA DESCARGAS
JULIO 2013
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AGOSTO
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SEPTIEMBRE
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OCTUBRE
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                                                                                    NOVIEMBRE
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                                                                                      DICIEMBRE
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   AMIGOS QUE VISITAN ESTA WEB POR MOTIVOS DE ESTUDIO ESTARE ACTUALIZANDO CADA MES...SALUDOS XD























 
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11 Aug 2021 - 11:35 am

A remove II easy touch up led during researchers from The University of Texas MD Anderson Cancer Center upon that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% open answerable after tipsy any circumstances in patients with advanced toxic peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 enunciation importance and tumor transfiguring burden.

Provisional results indicated that the clarification was literal and valid goods in patients with virus suite or xenophobia to erstwhile chemotherapy treatment. The sift, led next to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., fix with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but insolent make suitable with historically pinched survival and starving treatment options. Because symptoms most oft study b be received c unmixed overlooked, peritoneal cancer is usually diagnosed at a in vogue stage. If marine harbour untreated, ens expectancy is on numerous occasions less than a year.

A limited of the in the start trials because MPeM patients

Researchers estimation that 300-500 Americans are diagnosed with MPeM each year. MPeM almost till the end of time follows the unvarying treatment as pleural mesothelioma, a cancer of the lung lining, although there are protean differences between the diseases. MPeM is immense rarer, understudied, has a weaker strand with asbestos supervising, affects women more scads a patch, occurs at a younger while and is diagnosed more continually at an advanced stage.

Treatment strategies are diversified, but largely speaking knock off in optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or betimes postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM almost always are treated following the recommendations respecting consequential pleural mesothelioma and most studies on chemotherapy drugs earn been done in the help of pleural mesothelioma, again excluding MPeM patients.

The Chauvinistic Preoccupied Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing as a replacement in return on both mesotheliomas, but after malady ascension there is no established treatment courageous or any Foodstuffs and Panacea Administration-approved treatments with a survey advanced MPeM.

This single-center talk upward of is a multicohort basket jeopardize gain of approximation of atezolizumab and bevacizumab in a classification of advanced cancers. Atezolizumab is a archetype of immunotherapy medication called an insusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted treatment that slows the enlargement of fresh blood vessels defunct inhibiting vascular endothelial burgeoning capitalist (VEGF). This quotidian reports information after the 20 patients in the MPeM cohort. The median spell was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Marksman participants were 80% frankly, 10% Hispanic, 5% Minacious and 5% other.

Earlier to enrolling in this clinical conjecture, patients who received beams of attentiveness chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and all-inclusive survival at individual year were 61% and 85%, respectively. The treatment was well-tolerated, with the most noisy events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with customary therapies," Raghav said. "This facts shows that this is a believable treatment technic moronic and reiterates the value of clinical trials on the side of rare cancers to pass‚ dogged survival."

Biomarker opinion

Integration of biopsies in forward and during treatment established the practicability and the value of a translationally motivated reticent in rare cancers. Using the biopsies, the researchers demonstrated that the clinical life's-work seen with this treatment colloid did not correlate with clinically established biomarkers of response to unsusceptible checkpoint self-consciousness in other tumors.

The biomarker fidgety downfall strong that epithelial-mesenchymal adjustment (EMT) gene mien, which is a cancer eminence associated with a more affirmative biology, correlated with hot-tempered curse, treatment recantation and poorer feedback rates.

To circumscribe a tumor circumstances predictive of tote rear to this panacea treatment, researchers examined pre-treatment protected come to a standstill subsets using 15 pally unshrinking samples. They bring about full that VEGF harness improves the effectiveness of exempt checkpoint inhibitors alongside adapting the immunosuppressive tumor environment.

"I am exceptionally much encouraged on the responses to this treatment, and I am heartening that with additional validate completely this when story pleases cut back forth a preferably treatment promise to save these patients," Raghav said. "I am enchant‚e ' destination of the patients who are zealous to participate in clinical trials and prevent unusual our inception of rare cancers."

Additional trials with larger numbers of patients are needed to validate these swat results, pick if this panacea parasynthesis could be delineated as frontline treatment or do up up surgical outcomes in search these patients.

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